PITA Fiscal Year 2007 Projects

Biomedical and Health Engineering

Design Optimization of a Novel Thrombectomy Device for AV-Graft Declotting
One attractive avenue for treatment of blockages in arteriovenous (AV) grafts used for patients undergoing hemodialysis treatment is thrombectomy – the destruction of the offending clot via mechanical means. The feasibility of such approach is the subject of this research proposal. It is desirable to understand the fluid physics and mechanical reaction forces at the clot site of the said approach numerically before beginning expensive animal research (and ultimately human trials). Through collaboration with researchers at the Pittsburgh Supercomputing Center and Carnegie Mellon University, MEDRAD plans to characterize the fluid dynamics and optimize the current design of a specialized, therapeutic catheter. The knowledge gained from the CFD simulation will guide product designers to better understand the hazards and improve future designs.