PITA Fiscal Year 2009 Projects - Biomedical and Health Engineering

The Clinical Translation of Bioprinting Technology

Principal Investigators: Dr. Phil Campbell, Dr. Lee Weiss

The goal of this research is to demonstrate the translation of growth factor bioprinting technology to a clinically relevant animal model representing repair of tendon and bone, and their interface, associated with joint injuries and disease. Spatial patterns of multiple growth factors will be inkjet printed onto Dermatirx, which is an FDA approved biomaterial, and implanted into a mouse model. Multiple bioinks will be required to not only promote multiple tissue types, but also to inhibit tissues where we don’t want them to be. This is the way in which nature spatially controls tissue formation and repair, however, others of not yet taken advantage of this approach. The data obtained will be used in support of follow-on NIH grant proposals to progress to higher-order animal models and eventually to early clinical trials. Tendon/bone repair addresses important clinical needs across all patient age groups, from young to old, and for a broad range of applications such a maxillofacial reconstruction and orthopaedics such as for rotator cuff repair. These represent a multi-billon dollar a year dollar markets. The use of Dermatrix, which is already being successfully applied in the clinic for other applications, will lower the hurdles for FDA approval and thus speed adoption of our technology.