PITA Fiscal Year 2013 Projects

An Antimicrobial Prophylactic Biomaterial For Cardiac Implantable Electronic Devices

Lead University: Carnegie Mellon University
PI: Lee Weiss, Robotics Institute
Co-PI: Phil Campbell, ICES
PA Industry: Carmell Therapeutics Corp.

Permanently implantable cardiac pacemakers and cardioverter defibrillators, collectively known as cardiac implantable electronic devices (CIEDs), are being used increasingly because of the aging population. However, the number of infections associated with implantation of these devices has increased at an even higher rate, leading to higher expenditures for post-surgical treatment of infections and, in some cases, death. Antibiotic-eluting prophylactic devices implanted along with CIEDs mitigate against the development of these infections. Current prophylactic devices, however, also have several significant drawbacks related to issues of implant technique and, most importantly, their high cost, which has limited their widespread use. To address these issues we propose to develop an antibiotic-eluting bioresorbable biomaterial that can simply be injected around the CIED upon implantation and will cost at least three times less than current devices. This injectable biomaterial will also have unique bioactive properties that will enhance wound healing around the CIED implant site, which will further mitigate against infection.