Bioengineering Technologies
People | Projects
Tissue Engineering Technologies
Bioprinting
Inkjet-based bioprinting systems have been developed to create 2D and 3D patterns of
hormones and extracellular matrices in order to study cell behavioral responses in microenvironmental niches
and ultimately to help control stem cell fates in applications for nerative medicine.
Lee Weiss, Phil Campbell, Lynn Walker
Computer Vision-Based Cell Tracking
A real-time, automated cell tracking system is being developed to measure the
spatiotemporal histories of each individual cell within whole populations of cells in vitro to enable
high-throughout analysis of cell fates in response to microenvironmental niches and on-line process control
of stem cell expansion cultures for stem cell engineering applications.
Phil Campbell, Takeo Kanade, Lee Weiss
Protein-Based Plastics
Protein-based plastics derived from plasma, fibrin, gelatin, collagen, and
extracellular matricies are being developed that can be engineered with a wide range of material
properties which are applicable for soft and hard tissue regeneration.
Phil Campbell, Prashant Kumta, Lee Weiss
Non-Invasive Monitoring of Stem Cells and Tissue Engineered Scaffolds in Vivo
Fluorescent, x-ray and CT imaging toolsetsare being developed to non-invasively follow
the fate of implanted stem cells and/or remodeling of implanted scaffolds in animals.
Phil Campbell, Lee Weiss, Alan Waggoner, Marcel Bruchez
Fluorescent-Based Imaging of Cell Differentiation
Genetic and non-genetic fluorescent cell labeling strategie sare being developed to
enable non-invasive real-time monitoring of cell differentiation behaviors in vitro and in vivo.
Phil Campbell, Jonathan Jarvik, Marcel Bruchez
Cardiovascular Biomechanics and Medical Devices
Quantification of Regional Cardiovascular Deformation from Dynamic CT Data
Combining a tag-less tracking approach and a probabilistic method to optimize the
position of the tracked points at each consequent cardiac phase, we compute deformation maps for heart and
vascular structures from dynamic CT images.
Elena Di Martino, Isabella Verdinelli, Artur Dubrawski
Mechanics of the Left Atrium: Implications for Atrial Fibrillation
non linear dynamic models for the left atrium, obtained from high speed CT images, are
used to investigate the effects of mechanical stresses on atrium function.
Elena Di Martino
Stress-Modulated Remodeling of a Non-Homogeneous Body
the stress–modulated remodeling of a vessel wall when local variations in the
mechanical properties of the material exist is studied by means of a numerical approach.
Elena Di Martino
Biomechanical Studies of Abdominal Aortic Aneurysm Weakening
the risk of rupture of abdominal aortic aneurysms and its progression with
time is studied by means of a novel risk of rupture index.
Elena Di Martino
Biomechanics of Abdominal and Cerebral Aneurysms
As an aid in the clinical management of the aneurysms, computational models
of patient-specific abdominal and cerebral aneurysms have been developed, based on in vivo flow conditions,
as a predictive tool for aneurysm rupture.
Ender Finol
Fluid-Based Thrombectomy in AV Grafts
A novel interventional catheter has been designed and optimized by means of
computational fluid dynamics modeling to understand the fluid physics and mechanical reaction forces
at the clot site.
Ender Finol
Cerebral Protection in Endovascular Therapy
To address the problem of risk of embolization in carotid artery stenting (CAS), we
have evaluated the carotid artery flow dynamics in the presence of cerebral protection within the context of
assessing the design functionality of distal protection devices on the basis of an integrated computational
and experimental methodology.
Ender Finol
Mechanical Clot Entrapment in Stroke Management
A novel catheter-based device has been designed for the emergent endovascular treatment
(location, entrapment and removal) of blood clots in the middle cerebral arteries of patients suffering from
stroke.
Ender Finol
BioMEMs
Microminiature, Implantable, Wireless Strain Gage Arrays
In particular, intarosseous (embedded within bone) sensors are being developing
for a range of application, including: as a tool to gain new knowledge about bone regeneration and remodeling
at the micro-scale and to aid in the development and verification of new graft materials; to provide improved
and timely information in real-time for clinical management of osteogenic disease and trauma; and, to monitor
bionic interfaces in envisioned smart prosthesis.
Gary Fedder, Phil Campbell, Lee Weiss
Molecular Biosensors
By engineering natural proteins such as antibodies, enzymes and signaling proteins, a
whole generation of sensor molecules that change colors or light up during crucial intra-cellular event can be
used to study processes in living cells. These new technologies will be applied in multiple areas of biology
and medicine to understand the basic mechanisms of development and disease, and to microchip-based real-time
critical care monitoring.
Alan Rosenbloom, Alan Waggoner