Tissue Engineering Technologies
Inkjet-based bioprinted patterns of growth factors and other signaling molecules are used to drive stem cell populations toward multiple fates, in vitro and in vivo, in spatial registration to these patterns. The printed patterns can be used for basic biological discovery, and eventually patterns could also be used directly as tissue engineered therapies.
Phil Campbell, Lee Weiss
Non-Invasive Imaging of Tissue Engineered Construct Remodeling In Vivo
Fluorescent toolsets are being developed to non-invasively follow the fate of implanted stem cells and remodeling of implanted scaffolds in animals. The goal is to use these toolsets for biological discovery to aid therapy design.
Phil Campbell, Marcel Bruchez, and Byron Ballou
Computer Vision-Based Cell Tracking
A real-time, automated computer vision-based cell tracking system is being developed to measure the spatiotemporal histories of each individual cell within populations of cells in vitro. The goals are to use this system to enable high-throughout analysis of cell fates in response to microenvironmental niches, and for on-line process monitoring of stem cell expansion cultures.
Phil Campbell, Lee Weiss, and Takeo Kanade, in collaboration with Intel Corporation.
This is a new, exploratory initiative where electronic circuits embedded in scaffold materials are being developed that will degrade in and be resorbed by the body (including the electronics) after they are no longer needed. Power and data communication is provided by RF telemetry. The initial target application is an implantable electrical stimulator to stimulate bone tissue growth and repair.
Lee Weiss, Phil Campbell, Jeyanandh Paramesh, and Gary Fedder
Blood Plasma-Based Plastics
Biodegradable plastics are being made from platelet-rich plasma. These implantable bioactive materials are being investigated for use in the treatment of a wide range of injuries. This technology was recently been spun-off into a start-up company Carmell Therapeutics.
Phil Campbell and Lee Weiss
Cardiovascular Biomechanics and Medical Devices
Quantification of Regional Cardiovascular Deformation from Dynamic CT Data
Combining a tag-less tracking approach and a probabilistic method to optimize the position of the tracked points at each consequent cardiac phase, we compute deformation maps for heart and vascular structures from dynamic CT images.
Isabella Verdinelli, Artur Dubrawski
Mechanics of the Left Atrium: Implications for Atrial Fibrillation
non linear dynamic models for the left atrium, obtained from high speed CT images, are used to investigate the effects of mechanical stresses on atrium function.
Stress-Modulated Remodeling of a Non-Homogeneous Body
the stress–modulated remodeling of a vessel wall when local variations in the mechanical properties of the material exist is studied by means of a numerical approach.
Biomechanical Studies of Abdominal Aortic Aneurysm Weakening
the risk of rupture of abdominal aortic aneurysms and its progression with time is studied by means of a novel risk of rupture index.
Biomechanics of Abdominal and Cerebral Aneurysms
As an aid in the clinical management of the aneurysms, computational models of patient-specific abdominal and cerebral aneurysms have been developed, based on in vivo flow conditions, as a predictive tool for aneurysm rupture.
Fluid-Based Thrombectomy in AV Grafts
A novel interventional catheter has been designed and optimized by means of computational fluid dynamics modeling to understand the fluid physics and mechanical reaction forces at the clot site.
Cerebral Protection in Endovascular Therapy
To address the problem of risk of embolization in carotid artery stenting (CAS), we have evaluated the carotid artery flow dynamics in the presence of cerebral protection within the context of assessing the design functionality of distal protection devices on the basis of an integrated computational and experimental methodology.
Mechanical Clot Entrapment in Stroke Management
A novel catheter-based device has been designed for the emergent endovascular treatment (location, entrapment and removal) of blood clots in the middle cerebral arteries of patients suffering from stroke.
Microminiature, Implantable, Wireless Strain Gage Arrays
In particular, intarosseous (embedded within bone) sensors are being developing for a range of application, including: as a tool to gain new knowledge about bone regeneration and remodeling at the micro-scale and to aid in the development and verification of new graft materials; to provide improved and timely information in real-time for clinical management of osteogenic disease and trauma; and, to monitor bionic interfaces in envisioned smart prosthesis.
Gary Fedder, Phil Campbell, Lee Weiss
By engineering natural proteins such as antibodies, enzymes and signaling proteins, a whole generation of sensor molecules that change colors or light up during crucial intra-cellular event can be used to study processes in living cells. These new technologies will be applied in multiple areas of biology and medicine to understand the basic mechanisms of development and disease, and to microchip-based real-time critical care monitoring.
Alan Rosenbloom, Alan Waggoner