PITA Fiscal Year 2007 Projects

Biomedical and Health Engineering

Autologous Plastics
A process will be developed to manufacture biodegradable plastics from a patient’s own blood. These plastics can be engineered to have: 1) a range of biomechanical properties, ranging from elastic, to rubbery, to hard; 2) tailored degradation rates; 3) incorporated exogenous growth factors; and 4) controlled porosity. Autologous plastics could be safely used in many patient-specific applications including: tissue engineered scaffolds/grafts; packing graft materials, temporary fixation devices; surgical guides; and, prosthetic-to-tissue interfaces. Such plastics could also be typed for closest blood type match and stored for donor applications. The plastics we develop will be tested in vitro and in vivo in a rat spinal fusion model.